Woven bone (primary bone) – Appears in embryonic development and fracture repair, as it can be laid down rapidly.

Under the microscope, bone can be divided into two types: This matrix is organised into numerous thin layers, known as lamellae. These crystals associate with the collagen fibres, making bone hard and strong. In addition to collagen and the associated proteins usually found in connective tissue, bone is impregnated with mineral salts, in particular calcium hydroxyapatite crystals. The extracellular matrix (ECM) refers to the molecules that provide biochemical and structural support to the cells. It also plays a role in conditions such as o steoporosis. The balance of osteoblast to osteoclast activity is crucial in the maintenance of the tissue’s structural integrity.

Osteoclasts – Derived from monocytes and resorb bone by releasing H + ions and lysosomal enzymes.

They then monitor the minerals and proteins to regulate bone mass.

Osteocytes – As the osteoid mineralises, the osteoblasts become entombed between lamellae in lacunae where they mature into osteocytes.

This will later become calcified/mineralised to form bone. Osteoblasts – Synthesise uncalcified/unmineralised extracellular matrix called osteoid.Like any connective tissue, its components can be divided into cellular components and the extracellular matrix. Bone is a specialised form of connective tissue.

Flat bone examples